PLATE 01
A third lineage
In 2005 the lab described Th17 cells — a lineage of effector CD4 T cells apart from the Th1 and Th2 paradigms that had held for twenty years. The finding reordered how immunologists understand inflammation.
View exhibit →University of Alabama at Birmingham · Pathology & Microbiology
The immune system,
observed closely.
An ongoing study of the CD4 T cell — how it directs defense at the body's surfaces, and how its programs turn against the tissues they protect.
The Weaver Laboratory
Casey T. Weaver, MD
Wyatt & Susan Haskell Professor of Medical Excellence
Casey T. Weaver, MD
Wyatt & Susan Haskell Professor of Medical Excellence
Now showing
The Living Atlas
Eighty thousand cells of the infected mouse intestine, drawn from an atlas of over half a million and rendered live in your browser. Turn it in three dimensions; slice it by genotype, time, and tissue; paint it by the expression of a single gene.
The permanent collection
Four rooms
PLATE 02
The intestine, negotiated
The gut is the body's largest immune organ — a standing negotiation between tolerance and defense. We follow effector and regulatory T cells through that negotiation, in their native tissue.
View exhibit →PLATE 03
Defense, turned
The same pathways that protect the intestine can drive inflammatory bowel disease, colorectal cancer, and neonatal sepsis. We study the turn — and where it might be reversed.
View exhibit →PLATE 04
The living atlas
A working scientific instrument, hung as an exhibit: the lab's single-cell atlas of the infected intestine, explorable point by point.
Enter the exhibit →Notices