Foundations
Th17 biology
Our lab helped define the Th17 lineage. We continue to map how these cells develop, how they defend mucosal barriers, and how they drive inflammation when control is lost.
How CD4 T cells direct immunity — and what happens when they don't.
The Weaver Lab studies the development and function of CD4 T cells: how they orchestrate adaptive immunity in host defense, and how they become dysregulated in immune-mediated disease of the intestine and in colorectal cancer.
Research
Three questions, one cell
Tissue
Mucosal & intestinal immunity
We study how effector and regulatory CD4 T cells keep the intestine in balance, and how nuclear receptors and the microbiota tune that balance.
Disease
Dysregulation & disease
From inflammatory bowel disease to colorectal cancer and late-onset neonatal sepsis, we ask how T-cell programs go wrong and how they might be redirected.
Interactive
A single-cell atlas, live in your browser
Eighty thousand cells from the intestine of a mouse responding to infection, sampled from an atlas of over half a million and rendered with the lab's own visualization engine. Slice it by genotype, time point, and tissue compartment, or paint it by the expression of a gene.
News
From the lab
Selected work